So we've actually been seeing some headway on figuring out why people are getting banned from D2 over on L1T. My understanding is that some of the optimizations that esync and DXVK do are not agreeing with Activision and their trash anti-cheat.
I think that as long as you don't play competitive Crucible, you'll be fine. At least, that was my understanding. I'd take that with a mountain of salt though.